Cystathionine beta-synthase-like protein

Author: pnfq

August undefined, 2024

WebThe formation of cystathionine based on pyridoxal 5′-phosphate (PLP) from O and Cys phosphohomoserine is the initial step of the transsulfurylation pathway, which is catalyzed by cystathionine γ-synthase. Cystathionine γ-synthase is recognized as an essential enzyme for assimilation of Se because of its increased affinity for SeCys in ... WebCystathionine beta-synthase, along with vitamin B6, converts homocysteine to cystathionine (see Fig. 5-8). A deficiency of this enzyme leads to accumulation not only …

Antioxidants Free Full-Text The Role of Hydrogen Sulfide in …

WebFeb 1, 2012 · However, the pathway of cysteine biosynthesis was interrupted by a reaction catalyzed by the enzyme - cystathionine beta-synthase (CBS), which has no gene assignment in current S. meliloti genome annotation. In addition, production of CBS was observed in the proteomic assay as well . These evidences supported that the CBS … WebCystathionine beta-synthase (CBS) converts HCY to GSH via the transsulfuration pathway with vitamin B6 as cofactor [53–55] ( Fig. 3.2). The tripeptide GSH is the main antioxidant and detoxification molecule. Keeping the balance between methylation and transsulfuration depends on methionine levels and allosteric activation of CBS by SAM. ctb114w

Cystathionine β synthase participates in murine oocyte …

WebThe CBS gene provides instructions for making an enzyme called cystathionine beta-synthase. This enzyme acts in a chemical pathway and is responsible for using vitamin B6 to convert building block of proteins (amino acid) called homocysteine and serine to a molecule called cytathionine. Another enzyme then converts cystathionine to the amino ... WebBiosynthetically, cystathionine is generated from homocysteine and serine by cystathionine beta synthase (upper reaction in the diagram below). It is then cleaved … WebThe CBS gene provides instructions for making an enzyme called cystathionine beta-synthase. This enzyme acts in a chemical pathway and is responsible for using vitamin … ctb 120

IJMS Free Full-Text Selective Hepatic Cbs Knockout Aggravates …

Pharos : Target Details - CBSL

WebBackground: Hyperhomocysteinemia often results from vitamin deficiency and/or an unhealthy lifestyle. Because the condition is a risk factor for developing cerebrovascular disease or atherosclerosis, approaches that decrease plasma homocysteine level WebOct 12, 2024 · Hydrogen sulfide (H 2 S) is an identified and recognized gasotransmitter after nitric oxide and carbon oxide. As endogenous methionine catalysis production, H 2 S major generates from homocysteine trans-sulfide metabolism. Cystathionine β synthase (CBS), cystathionine γ lyase (CSE), cysteine aminotransferase (CAT), and 3-mercaptopyruvate … earring metal that doesn\u0027t tarnishWebDec 9, 2024 · Many enzymes require pyridoxal 5’-phosphate (PLP) as an essential cofactor and share active site residues in mediating diverse enzymatic reactions. Methionine can be converted into cysteine by cystathionine γ-lyases (CGLs) through a transsulfuration reaction dependent on PLP. In bacteria, MccB, also known as YhrB, exhibits CGL activity … ctb1202/4bk

"Webcystathionine-beta-synthase ELISA Kits Provided below are ELISA kits targeting cystathionine beta-synthase, a human protein encoded by CBS. This protein is 551 amino acids long with a reported mass of 60.6 kDa. It is also an enzyme classified as a (n) cystathionine beta-synthase. " - Cystathionine beta-synthase-like protein

Cystathionine beta-synthase-like protein

WebCystathionine beta-synthase (CBS) converts HCY to GSH via the transsulfuration pathway with vitamin B6 as cofactor [53–55] ( Fig. 3.2 ). The tripeptide GSH is the main antioxidant and detoxification molecule. Keeping the balance between methylation and transsulfuration depends on methionine levels and allosteric activation of CBS by SAM. WebApr 10, 2024 · Cystathionine-β-synthase (CBS) is highly expressed in the liver, and deficiencies in Cbs lead to hyperhomocysteinemia (HHCy) and disturbed production of antioxidants such as hydrogen sulfide. We therefore hypothesized that liver-specific Cbs deficient (LiCKO) mice would be particularly susceptible to the development of non …

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WebFeb 12, 2024 · The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine … WebFeb 6, 2024 · Cystathionine-β-synthase (CBS) is a modular enzymatic protein of 551 amino acids. The lyase CBS acts in the transsulfuration pathway and has a central role in the mammalian sulfur metabolism by ...

WebOur previous study demonstrated that cystathionine β synthase (CBS) is highly expressed in the cumulus–oocyte complex during ovulation. However, the role of CBS during oocyte maturation remains uncertain. In this study, a small-interfering (si) RNA interference (siRNA) approach was used to investigate the potential role of CBS during oocyte maturation. WebThe CBS (Cystathionine Beta Synthase) gene, located on chromosome 21 in humans, encodes a pyridoxal 5′-phosphate-dependent enzyme catalysing the condensation of …

WebSep 2, 2014 · Cystathionine β-synthase (CBS) is a heme-dependent and pyridoxal-5′-phosphate–dependent protein that controls the flux of sulfur from methionine to cysteine, a precursor of glutathione, taurine, and H 2 S. Deficiency of CBS activity causes homocystinuria, the most frequent disorder of sulfur amino acid metabolism. In contrast … WebIn molecular biology, the CBS domain is a protein domain found in a range of proteins in all species from bacteria to humans. It was first identified as a conserved sequence region in 1997 and named after cystathionine beta synthase, one of the proteins it is found in. CBS domains are also found in a wide variety of other proteins such as inosine …

WebDec 8, 2024 · 102724560 - Gene ResultLOC102724560 cystathionine beta-synthase like [ (human)] LOC102724560 cystathionine beta-synthase like [ (human)] Gene ID: 102724560, updated on 5-Aug-2024 Summary Other designations cystathionine beta-synthase, beta-thionase, cystathionine beta-synthase-like protein, serine sulfhydrase

WebMar 29, 2024 · The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. ctb04WebMutations in the CBS, MTHFR, MTR, MTRR, and MMADHC genes cause homocystinuria.. Mutations in the CBS gene cause the most common form of homocystinuria. The CBS … ct-b10b ctb100 fridge compressorWebOct 18, 2006 · We demonstrate that CBS is modified by the small ubiquitin-like modifier-1 protein (SUMO-I) under both in vitro and in vivo conditions. Deletion analysis of CBS indicates that the C-terminal regulatory domain is required for interaction with proteins in the sumoylation machinery. ... Cystathionine Beta Synthase Expression in Mouse Retina ... ctb1016g factory resetWebMar 23, 2024 · Cystathionine β -synthase (CBS) regulates homocysteine metabolism and contributes to hydrogen sulfide (H 2 S) biosynthesis through which it plays multifunctional roles in the regulation of cellular energetics, redox status, DNA methylation, and protein modification. Inactivating mutations in CBS contribute to the pathogenesis of the … earring nameplatesWebJan 10, 2024 · LOC102724560 (Cystathionine Beta-Synthase Like) is a Protein Coding gene. Among its related pathways are Cysteine formation from homocysteine and One … ctb1140WebCystathionine beta-lyase MetC Gene metC Status UniProtKB reviewed (Swiss-Prot) Organism Escherichia coli (strain K12) Amino acids 395 Protein existence Evidence at protein level Annotation score 5/5 Entry Feature viewer Publications External links History BLAST Download Add a publication Entry feedback Function ctb1280-20-cw