WebJul 29, 2009 · This review will highlight recent examples from the literature that have successfully integrated genetic and genomic approaches to uncover the molecular basis … WebCis-acting elements are not part of the coding sequences of the gene they regulate: they may be near the promoter or the 5’ region of the gene, and in some cases they may be many kilobases...

Candidate silencer elements for the human and mouse genomes

An example of a cis-acting regulatory sequence is the operator in the lac operon. This DNA sequence is bound by the lac repressor, which, in turn, prevents transcription of the adjacent genes on the same DNA molecule. The lac operator is, thus, considered to "act in cis" on the regulation of the nearby … See more Cis-regulatory elements (CREs) or Cis-regulatory modules (CRMs) are regions of non-coding DNA which regulate the transcription of neighboring genes. CREs are vital components of genetic regulatory networks, … See more Cis-regulatory modules can be characterized by the information processing that they encode and the organization of their transcription factor binding sites. … See more The function of a gene regulatory network depends on the architecture of the nodes, whose function is dependent on the multiple cis-regulatory modules. The layout of cis-regulatory modules can provide enough information to generate spatial and … See more Besides experimentally determining CRMs, there are various bioinformatics algorithms for predicting them. Most algorithms try to … See more The genome of an organism contains anywhere from a few hundred to thousands of different genes, all encoding a singular product … See more CREs have an important evolutionary role. The coding regions of genes are often well conserved among organisms; yet different organisms display marked phenotypic diversity. It has … See more Cis-regulatory modules can regulate their target genes over large distances. Several models have been proposed to describe the way that these modules may communicate with … See more WebDec 6, 2011 · Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence. Cis-regulatory sequences, such as enhancers and promoters, … dutch singapore

regulatory elements: methods of identification and …

WebFor example, the different members of a storage protein or photosynthetic protein family are expressed at the same time in development. These genes have sequence modules in … WebDec 23, 2024 · We first exploit and analyze auxin-specific cis-regulatory elements for the transcription of the target genes, and then identify putative auxin responsive genes whose promoters contain the elements in the collection of over 25,800 promoters in the A. thaliana genome. ... For example, the shortest chromosome, chromosome 4, contains almost the ... WebApr 15, 2024 · Differential gene expression mechanisms ensure cellular differentiation and plasticity to shape ontogenetic and phylogenetic diversity of cell types. A key regulator of differential gene expression programs are the enhancers, the gene-distal cis-regulatory sequences that govern spatiotemporal and quantitative expression dynamics of target … dutch singles dating site